Multifunctional Enzymes in Microbial Secondary Metabolic Processes

Microorganisms possess a strong capacity for secondary metabolite synthesis, which is represented by tightly controlled networks. The absence of any enzymes leads to change in the original metabolic pathway, with decrease or even elimination synthetic product, not permissible under conditions normal life activities microorganisms. In order improve efficiency metabolism, organisms have evolved multifunctional (MFEs) that can catalyze two more kinds reactions via multiple active sites. However, instead interfering, catalytic properties MFEs facilitate biosynthetic process. Among numerous considered vital importance living are synthases involved assembling backbone compounds using different substrates and modifying confer final activity compounds. this paper, we review terms both post-modifying biosynthesis, focusing on polyketides, non-ribosomal peptides, terpenoids, wide range cytochrome P450s(CYP450s), provide an overview describe recent progress research MFEs.